The TGA lied in their FOIs about testing.
Basic genomes lesson – mRNA has four nucleotides – Adenine, Cytosine, Guanine and Uracil. Any three makes a codon. Therefore there can be 64 different types of codons. (4x4x4) Every codon has a purpose which is translated by the ribosome in a cell. Some combinations translate the codons into an amino acid and some codons give instructions. Three Uracil’s in a row give the ribosome the instruction to stop translating codons into amino acids.
This is basic textbook biochemistry.
A few years ago a doctor with a PHD in genomics from Cambridge asked the TGA if replacing Uracil with methylpsuedouridine in the mRNA jab would result in “codon read through” because the ribosome would not recognise the synthetic (I.e.manmade) codon and keep translating the mRNA resulting in deformed proteins being made by your cells causing all sorts of harm.
The TGA of course replied they had no documents to that effect.
In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a nonsense codon, or a premature stop codon in the transcribed mRNA, and leads to a truncated, incomplete, and possibly nonfunctional protein product. Testing showed the mRNA vaccines had produced many truncated proteins.
It turns out that tests had been carried out (not by Pfizer or the TGA of course) showing that using methylpsuedouridine did result in codon read through.
I asked the TGA about this in estimates. Of course they took it on notice only to reply with a straight out lie claiming the test put the codon in a premature position. Ribosomes have no idea what a premature position is, they just read the codon regardless of what codons precede it.
Furthermore the claim they have three stop codons doesn’t cut it either. A leaky bucket is a leaky bucket. If the ribosome doesn’t recognise methylpseudouridine then it doesn’t matter how many codons are put in.
Long story short, not only did the TGA not do any testing on the use of methylpsuedouridine they are now lying about it.
Quote from:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7430670/
Community Affairs Legislation Committee
07/11/2024
Estimates
HEALTH AND AGED CARE PORTFOLIO
Therapeutic Goods Administration
Senator RENNICK: I also have some prior dialogue between me and Professor Skerritt in the Hansard where he said that there’s no evidence that the stop codon readthrough occurs in regards to the mRNA vaccine. I’ve found a study that goes back to about 2011 that shows that the use of methylpseudouridine did actually have stop codon readthrough. I’m curious to know why this wasn’t picked up by the TGA, because there was another FOI 3604, a question put to the TGA about that stop codon readthrough. He said he had no records in regards to that. It would appear that there is actually evidence that there is stop codon readthrough when you use methylpseudouridine instead of uridine.
Dr Kerr : The evidence provided to the TGA doesn’t show that there’s stop codon readthrough. The stop codon readthrough was evaluated as part of the pre-market submission and found to be acceptable.
Senator RENNICK: I’m happy to table this document here that says there were similar levels of stop codon readthrough. This was a study done in 2015—or 2020. I’m just asking why the TGA wouldn’t have been aware of the stop codon readthrough risk, or why it didn’t address this FOI.
Prof. Lawler : As I think Dr Kerr has just indicated, we were aware of the nature of the stop codon readthrough functions. I think you cited FOI 3390 document 11. Is that correct?
Senator RENNICK: Yes. That’s not to do with stop codon readthrough. This is FOI 3604.
Prof. Lawler : I also would highlight then question on notice SQ24-000236. You did ask the question: ‘Why did Pfizer feel the need to insert three stop codons? And do the stop codons work for methylpseudouridine?’ We responded to that, and we provided an answer.
Senator RENNICK: I know you did, and now I’ve subsequently found a study that says that stop codon readthrough does occur. Professor Skerritt said there was no evidence that it did occur, and I’ve actually found evidence, prior to the rollout of the vaccine, that it did occur.
Prof. Lawler : On the basis of that study—which, as I said, we don’t have in front of us—if you’d like us to respond to that, we can do that.
Senator RENNICK: I can do that. That’s fine.
