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1. Has the Office of Gene Technology performed any toxicity testing on the vaccines yet? If not, why not? Should the OGT be involved given the use of Gene Technology. 2. No spike protein was tested in the animal trials. Instead, luciferase was tested. Can the OGT please give its opinion on the quality assurance around testing conducted by Pfizer when it ignored including such a vital ingredient? 5. Can the OGT quantify how much the lifespan of mRNA will increase due to the addition 70 adenine nucleotides to the poly tail A? If not, why not? 6. What tests have been conducted to ensure that that proline insertion will actually keep the spike protein in its prefusion shape? If the shape of the spike protein changes then does the OGT acknowledge that any antibodies generated by the vaccine will be ineffective because the spike protein generated by the vaccine will have a different shape to the virus spike protein? 7. Has the OGT conducted tests to determine the degradation and distribution of the lipids and spike protein. If not, why not? 8. The TGA non-clinical report on page 8 says that the spike protein can be created in the endoplasmic reticulum and can either be inserted into the membrane or secreted from the cell. What studies has the OGT undertaken to determine just how much spike protein is secreted from the bodies cells, which organs secrete the most proteins and how those proteins are cleared from the body? If not, why not? 9. When the spike protein is inserted into the membrane of the cell what studies has the OGT undertaken to determine the autoimmune response of the body in regards to disposing of cells that contain the spike protein? 10. Professor Murphy said in estimates that only the spike protein is removed from the cell membrane, and that the cell itself wasn’t destroyed. Is this correct? I note the TGA nonclinical reported the vaccine induced a CD8 response that destroy cells infected with viruses. 11. What is the different 5 cap structure in modified RNA – as page 109 FOI 2389-3? 12. Is the 3 cap structure in modified RNA the same as the 3 cap in virus spike protein? If not, what is the difference?

Question Number: 139
PDR Number: SQ22-000503
Date Submitted: 21/11/2022
Department or Body: Department of Health

The Office of the Gene Technology Regulator (OGTR) has no regulatory role in the assessment and approval of mRNA COVID-19 vaccines.

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